Product Data Sheet
CJ-15208
Catalog No. A62581
CJ-15208 is a potent and selective κ-opioid receptor antagonist with notable analgesic properties. In preclinical studies, it demonstrated significant analgesic effects in the warm water tail withdrawal test in mice, mediated through multiple opioid receptors. Distinct stereoisomers of CJ-15208 exhibit varying opioid activity characteristics; one stereoisomer antagonizes κ-opioid receptors, while another targets δ-opioid receptors. Importantly, none of the stereoisomers affected respiration or induced drug tolerance, highlighting CJ-15208's potential for development as a safer alternative in opioid analgesics.
Chemical Information
| Catalog Num | A62581 |
|---|---|
| M. Wt | 577.67 |
| Formula | C34H35N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 210236-47-8 |
| Synonyms | |
| SMILES | O=C(N[C@H](C(N1[C@@](CCC1)([H])C(N[C@H](C(N2)=O)CC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)[C@@H]2CC5=CNC6=CC=CC=C56 |
Biological Activity
| Description | CJ-15208 is a potent and selective κ-opioid receptor antagonist with notable analgesic properties. In preclinical studies, it demonstrated significant analgesic effects in the warm water tail withdrawal test in mice, mediated through multiple opioid receptors. Distinct stereoisomers of CJ-15208 exhibit varying opioid activity characteristics; one stereoisomer antagonizes κ-opioid receptors, while another targets δ-opioid receptors. Importantly, none of the stereoisomers affected respiration or induced drug tolerance, highlighting CJ-15208's potential for development as a safer alternative in opioid analgesics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
