Product Data Sheet
YL-365
Catalog No. A62753
YL-365 is a potent and selective antagonist of the GPR34 receptor, exhibiting an IC50 value of 17 nM. By binding to a specific region within the orthosteric binding pocket, YL-365 induces allosteric modifications that stabilize the receptor in an inactive state. It effectively down-regulates the pro-inflammatory gene iNOS in M1 microglia, consequently suppressing pro-inflammatory responses. Additionally, YL-365 demonstrates dose-dependent reduction of mechanical allodynia in mouse models of neuropathic pain, making it a valuable tool for studying inflammatory mechanisms and potential treatments for neuropathic conditions.
Chemical Information
| Catalog Num | A62753 |
|---|---|
| M. Wt | 583.07 |
| Formula | C34H31ClN2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3077715-58-0 |
| Synonyms | |
| SMILES | O=C(NC1(C(O)=O)CCN(C(C2=CC=C(C3=CC=CC(Cl)=C3)C=C2)=O)CC1)CC4=CC=C(OCC5=CC=CC=C5)C=C4 |
Biological Activity
| Description | YL-365 is a potent and selective antagonist of the GPR34 receptor, exhibiting an IC50 value of 17 nM. By binding to a specific region within the orthosteric binding pocket, YL-365 induces allosteric modifications that stabilize the receptor in an inactive state. It effectively down-regulates the pro-inflammatory gene iNOS in M1 microglia, consequently suppressing pro-inflammatory responses. Additionally, YL-365 demonstrates dose-dependent reduction of mechanical allodynia in mouse models of neuropathic pain, making it a valuable tool for studying inflammatory mechanisms and potential treatments for neuropathic conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
