Product Data Sheet
NF157
Catalog No. A62814
NF157 is a selective antagonist of the P2Y11 receptor, exhibiting a pKi of 7.35 and an IC50 of 463 nM. It demonstrates high specificity, with significantly higher IC50 values for related receptors P2Y1 and P2Y2. NF157 is known to reduce the expression of metalloproteinases (MMP)-3 and MMP-13, making it a valuable tool for research into osteoarthritis and related inflammatory conditions.
Chemical Information
| Catalog Num | A62814 |
|---|---|
| M. Wt | 1437.10 |
| Formula | C49H28F2N6Na6O23S6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 104869-26-3 |
| Synonyms | |
| SMILES | O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5 |
Biological Activity
| Description | NF157 is a selective antagonist of the P2Y11 receptor, exhibiting a pKi of 7.35 and an IC50 of 463 nM. It demonstrates high specificity, with significantly higher IC50 values for related receptors P2Y1 and P2Y2. NF157 is known to reduce the expression of metalloproteinases (MMP)-3 and MMP-13, making it a valuable tool for research into osteoarthritis and related inflammatory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
