Product Data Sheet
Apafant-d8
Catalog No. A62939
Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling.
Chemical Information
| Catalog Num | A62939 |
|---|---|
| M. Wt | 464.01 |
| Formula | C22H14D8ClN5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1185101-22-7 |
| Synonyms | WEB 2086-d8 |
| SMILES | O=C(N1C([2H])([2H])C([2H])([2H])OC([2H])([2H])C1([2H])[2H])CCC2=CC3=C(S2)N4C(CN=C3C5=C(C=CC=C5)Cl)=NN=C4C |
Biological Activity
| Description | Apafant-d8 is a deuterium-labeled derivative of Apafant, a potent antagonist of platelet-activating factor (PAF). It effectively inhibits PAF binding to human PAF receptors with an IC50 value of 9.9 nM. Apafant-d8 enhances the expression of PAF receptor, α-globin, and β-globin genes while reducing c-myb gene expression. This compound also demonstrates protective effects against alkyl-PAF-mediated cytotoxicity, making it valuable for research in cellular protection and receptor signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
