Product Data Sheet
A457
Catalog No. A63001
A457 is a selective antagonist of the prokineticin receptor PKR2, exhibiting an IC50 value of 102 nM. This compound effectively restores cell surface expression and functionality of the P290S PKR2 variant, while showing no activity against the W178S and G234D PKR2 mutations. A457 is valuable for research applications focused on the modulation of PKR2-related pathways and the study of receptor mutations.
Chemical Information
| Catalog Num | A63001 |
|---|---|
| M. Wt | 457.00 |
| Formula | C26H33ClN2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1233923-95-9 |
| Synonyms | |
| SMILES | O=C(N(CC(C)C)CC1=CC(Cl)=C2OCCCOC2=C1)C3CN(CC3)CC4=CC=CC=C4 |
Biological Activity
| Description | A457 is a selective antagonist of the prokineticin receptor PKR2, exhibiting an IC50 value of 102 nM. This compound effectively restores cell surface expression and functionality of the P290S PKR2 variant, while showing no activity against the W178S and G234D PKR2 mutations. A457 is valuable for research applications focused on the modulation of PKR2-related pathways and the study of receptor mutations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
