Product Data Sheet
NTP42
Catalog No. A63022
NTP42 is a potent thromboxane A2 (TXA2) receptor antagonist, exhibiting an IC50 of 3.278 nM in inhibiting T prostanoid receptor (TP)-mediated [Ca2+] mobilization upon stimulation with the alternative TP agonist U46619. This compound is particularly relevant for research applications targeting pulmonary arterial hypertension (PAH), offering potential therapeutic avenues for addressing this condition through TXA2 modulation.
Chemical Information
| Catalog Num | A63022 |
|---|---|
| M. Wt | 515.53 |
| Formula | C25H23F2N3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2055599-51-2 |
| Synonyms | |
| SMILES | O=S(C1=CC(C#N)=CC=C1OC2=CC(C3=CC=C(OC(F)F)C=C3)=CC=C2)(NC(NC(C)(C)C)=O)=O |
Biological Activity
| Description | NTP42 is a potent thromboxane A2 (TXA2) receptor antagonist, exhibiting an IC50 of 3.278 nM in inhibiting T prostanoid receptor (TP)-mediated [Ca2+] mobilization upon stimulation with the alternative TP agonist U46619. This compound is particularly relevant for research applications targeting pulmonary arterial hypertension (PAH), offering potential therapeutic avenues for addressing this condition through TXA2 modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
