Product Data Sheet
AAT-008
Catalog No. A63055
AAT-008 is a selective and orally active antagonist of the prostaglandin EP4 receptor, exhibiting Ki values of 0.97 nM for recombinant human EP4 and 6.1 nM for recombinant rat EP4. This compound demonstrates significant tumor growth delay in murine models of CT26WT colon tumors when used in conjunction with radiotherapy. AAT-008 is valuable for investigating acute and chronic inflammatory pain, as well as cancer-related research applications.
Chemical Information
| Catalog Num | A63055 |
|---|---|
| M. Wt | 414.81 |
| Formula | C21H16ClFN2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 847727-81-5 |
| Synonyms | |
| SMILES | O=C(O)C1=CC=C([C@@H](NC(C2=CC(Cl)=CN=C2OC3=CC=CC(F)=C3)=O)C)C=C1 |
Biological Activity
| Description | AAT-008 is a selective and orally active antagonist of the prostaglandin EP4 receptor, exhibiting Ki values of 0.97 nM for recombinant human EP4 and 6.1 nM for recombinant rat EP4. This compound demonstrates significant tumor growth delay in murine models of CT26WT colon tumors when used in conjunction with radiotherapy. AAT-008 is valuable for investigating acute and chronic inflammatory pain, as well as cancer-related research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
