Product Data Sheet
Nepafenac-d5
Catalog No. A63080
Nepafenac-d5 is a deuterated derivative of Nepafenac, a nonsteroidal anti-inflammatory drug that functions primarily as a topical COX-2 inhibitor with an IC50 of 0.12 μM. This compound exhibits minimal COX-1 inhibition (IC50 = 64.3 μM) and possesses prodrug characteristics, allowing it to rapidly convert to the active metabolite Amfenac in ocular tissues. Nepafenac-d5 is employed in research to investigate its efficacy in reducing inflammation and managing pain following ophthalmic procedures, as well as its potential to inhibit uveal melanoma metastasis in preclinical models.
Chemical Information
| Catalog Num | A63080 |
|---|---|
| M. Wt | 259.31 |
| Formula | C15H9D5N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246814-53-8 |
| Synonyms | AHR-9434-d5; AL-6515-d5 |
| SMILES | O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])C2=CC=CC(CC(N)=O)=C2N |
Biological Activity
| Description | Nepafenac-d5 is a deuterated derivative of Nepafenac, a nonsteroidal anti-inflammatory drug that functions primarily as a topical COX-2 inhibitor with an IC50 of 0.12 μM. This compound exhibits minimal COX-1 inhibition (IC50 = 64.3 μM) and possesses prodrug characteristics, allowing it to rapidly convert to the active metabolite Amfenac in ocular tissues. Nepafenac-d5 is employed in research to investigate its efficacy in reducing inflammation and managing pain following ophthalmic procedures, as well as its potential to inhibit uveal melanoma metastasis in preclinical models. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
