Product Data Sheet
15(R)-15-Methyl prostaglandin D2
Catalog No. A63087
15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies.
Chemical Information
| Catalog Num | A63087 |
|---|---|
| M. Wt | 366.49 |
| Formula | C21H34O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 210978-26-0 |
| Synonyms | 15(R)-15-Methyl PGD2 |
| SMILES | CCCCC[C@@](C)(O)/C=C/[C@@H]1[C@H]([C@@H](O)CC1=O)C/C=C\CCCC(O)=O |
Biological Activity
| Description | 15(R)-15-Methyl prostaglandin D2 is a metabolically stable synthetic analog of PGD2 that selectively targets the CRTH2/DP2 receptor. This compound is known for its potent biological activities, including the regulation of eosinophil functions such as CD11b expression, actin polymerization, and chemotaxis, with EC50 values of 1.4, 3.8, and 1.7 nM, respectively. Its efficacy in these activities is significantly greater compared to natural PGD2. Additionally, 15(R)-15-Methyl prostaglandin D2 shows minimal action on the DP1 receptor, making it a valuable tool for research in immunology and inflammation studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
