Product Data Sheet
(+)-JJ-450
Catalog No. A63122
(+) -JJ-450 is a non-competitive antagonist of the androgen receptor (AR), effectively inhibiting AR nuclear localization and transcriptional activity in the absence of androgen. This compound promotes the degradation of unliganded AR within the nucleus, thereby reducing the binding of AR to androgen response elements (AREs), including its splice variants like ARv7. With lower efficacy than its counterpart, (-)-JJ-450, in suppressing prostate-specific antigen (PSA) expression in LN95 cells, (+)-JJ-450 is particularly relevant for research focused on castration-resistant prostate cancer (CRPC) that exhibits resistance to enzalutamide.
Chemical Information
| Catalog Num | A63122 |
|---|---|
| M. Wt | 372.86 |
| Formula | C21H22ClFN2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1998094-24-8 |
| Synonyms | |
| SMILES | O=C([C@@H]1C[C@@H]1C2=CC=C(C=C2)F)N3CCN(CC3)C4=CC(Cl)=CC=C4C |
Biological Activity
| Description | (+) -JJ-450 is a non-competitive antagonist of the androgen receptor (AR), effectively inhibiting AR nuclear localization and transcriptional activity in the absence of androgen. This compound promotes the degradation of unliganded AR within the nucleus, thereby reducing the binding of AR to androgen response elements (AREs), including its splice variants like ARv7. With lower efficacy than its counterpart, (-)-JJ-450, in suppressing prostate-specific antigen (PSA) expression in LN95 cells, (+)-JJ-450 is particularly relevant for research focused on castration-resistant prostate cancer (CRPC) that exhibits resistance to enzalutamide. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
