Product Data Sheet
ICI 185282
Catalog No. A63137
ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions.
Chemical Information
| Catalog Num | A63137 |
|---|---|
| M. Wt | 374.35 |
| Formula | C18H21F3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 106393-80-0 |
| Synonyms | |
| SMILES | O=C(O)CCC/C=C\C[C@@H]1[C@H](C2=CC=CC=C2O)O[C@H](C(F)(F)F)OC1 |
Biological Activity
| Description | ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
