Product Data Sheet
ASP7657 free base
Catalog No. A63170
ASP7657 free base is a potent orally active antagonist of the EP4 receptor, exhibiting binding affinities (Kis) of 2.21 nM for human EP4 and 6.02 nM for rat EP4 receptors. This compound demonstrates significant biological activity in modulating inflammatory responses and is particularly useful in research focused on conditions related to pain, inflammation, and various immune disorders. Its selective action on the EP4 receptor makes it an important tool for investigating therapeutic strategies in relevant disease models.
Chemical Information
| Catalog Num | A63170 |
|---|---|
| M. Wt | 509.52 |
| Formula | C28H26F3N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1196045-28-9 |
| Synonyms | |
| SMILES | O=C([C@H]1CC[C@H](CNC(C2=CC(C(F)(F)F)=CC3=C2N(CC4=NC5=CC=CC=C5C=C4)C=C3)=O)CC1)O |
Biological Activity
| Description | ASP7657 free base is a potent orally active antagonist of the EP4 receptor, exhibiting binding affinities (Kis) of 2.21 nM for human EP4 and 6.02 nM for rat EP4 receptors. This compound demonstrates significant biological activity in modulating inflammatory responses and is particularly useful in research focused on conditions related to pain, inflammation, and various immune disorders. Its selective action on the EP4 receptor makes it an important tool for investigating therapeutic strategies in relevant disease models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
