Product Data Sheet
AH22921
Catalog No. A63181
AH22921 is a selective antagonist of the EP4 prostaglandin receptor, inhibiting the activation of adenylate cyclase by prostaglandins in CHO cells. This compound is characterized by its ability to shift the PGE2 concentration-response curve to the right, demonstrating its non-competitive antagonistic effect specifically on EP4 receptors. Notably, AH22921 does not influence the PGE2 concentration-response curve in NPE cells that express EP2 receptors, making it a valuable tool for studying EP4 receptor signaling in varied biological contexts.
Chemical Information
| Catalog Num | A63181 |
|---|---|
| M. Wt | 477.59 |
| Formula | C29H35NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 74480-23-2 |
| Synonyms | |
| SMILES | OC(CCC/C=C/C[C@H]1[C@H](N2CCOCC2)C(C[C@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3)=O)=O |
Biological Activity
| Description | AH22921 is a selective antagonist of the EP4 prostaglandin receptor, inhibiting the activation of adenylate cyclase by prostaglandins in CHO cells. This compound is characterized by its ability to shift the PGE2 concentration-response curve to the right, demonstrating its non-competitive antagonistic effect specifically on EP4 receptors. Notably, AH22921 does not influence the PGE2 concentration-response curve in NPE cells that express EP2 receptors, making it a valuable tool for studying EP4 receptor signaling in varied biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
