Product Data Sheet
TG11-77 hydrochloride
Catalog No. A63226
TG11-77 hydrochloride is a highly selective antagonist of the EP2 receptor, demonstrating potent inhibition with a KB value of 9.7 nM. This compound effectively blocks PGE2-induced activation of the human EP2 receptor, leading to significant anti-inflammatory effects. TG11-77 hydrochloride has also been shown to reduce delayed mortality and mitigate memory deficits, making it a valuable tool for research in neuroinflammation and related therapeutic areas.
Chemical Information
| Catalog Num | A63226 |
|---|---|
| M. Wt | 436.94 |
| Formula | C23H25ClN6O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2550393-38-7 |
| Synonyms | |
| SMILES | O=C(C1=CN=C(NC2=CC(C)=CC(C)=N2)N=C1)NCCC3=C(C)NC4=C3C=CC=C4.Cl |
Biological Activity
| Description | TG11-77 hydrochloride is a highly selective antagonist of the EP2 receptor, demonstrating potent inhibition with a KB value of 9.7 nM. This compound effectively blocks PGE2-induced activation of the human EP2 receptor, leading to significant anti-inflammatory effects. TG11-77 hydrochloride has also been shown to reduce delayed mortality and mitigate memory deficits, making it a valuable tool for research in neuroinflammation and related therapeutic areas. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
