Product Data Sheet
16(R)-AFP 07 free acid
Catalog No. A63429
16(R)-AFP 07 free acid is a potent prostaglandin analog targeting the IP receptor, which is critical for inhibiting platelet aggregation and promoting vasodilation in the pulmonary vascular system. As a 7,7-difluoroprostacyclin derivative, it exhibits high selectivity and potency for the IP receptor (Ki = 0.561 nM). While its affinity for EP receptors is significantly lower, with Ki values exceeding 100 nM for EP1-3 and >10 nM for EP4, the full extent of 16(R)-AFP 07's biological activity, particularly at the IP and EP receptors, warrants further investigation. This compound is relevant for studies exploring vascular functions and anti-thrombotic applications.
Chemical Information
| Catalog Num | A63429 |
|---|---|
| M. Wt | 412.47 |
| Formula | C22H30F2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 773825-80-2 |
| Synonyms | |
| SMILES | O=C(O)CCC/C=C1C(F)(F)[C@@]([C@@H](/C=C/[C@H](O)[C@@H](C)CC#CCC)[C@H](O)C2)([H])[C@@]2([H])O/1 |
Biological Activity
| Description | 16(R)-AFP 07 free acid is a potent prostaglandin analog targeting the IP receptor, which is critical for inhibiting platelet aggregation and promoting vasodilation in the pulmonary vascular system. As a 7,7-difluoroprostacyclin derivative, it exhibits high selectivity and potency for the IP receptor (Ki = 0.561 nM). While its affinity for EP receptors is significantly lower, with Ki values exceeding 100 nM for EP1-3 and >10 nM for EP4, the full extent of 16(R)-AFP 07's biological activity, particularly at the IP and EP receptors, warrants further investigation. This compound is relevant for studies exploring vascular functions and anti-thrombotic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
