Product Data Sheet
PAR3 (1-6) (human)
Catalog No. A63488
PAR3 (1-6) is a synthetic peptide that functions as an agonist for the protease-activated receptor (PAR1). This peptide corresponds to the first six residues of the amino-terminal tethered ligand sequence from human PAR3 and residues 39-44 from the full-length human sequence. PAR3 (1-6) effectively activates p42/44 MAPK signaling pathways in fibroblasts that express PAR1, an activation that can be inhibited by the PAR1 antagonist RWJ 56110. This reagent is valuable for research involving receptor signaling mechanisms and cellular responses to proteolytic activation.
Chemical Information
| Catalog Num | A63488 |
|---|---|
| M. Wt | 647.72 |
| Formula | C29H45N9O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 320347-28-2 |
| Synonyms | TFRGAP |
| SMILES | C([C@@H](NC(CNC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H]([C@@H](C)O)N)=O)=O)CCCNC(=N)N)=O)=O)C)(=O)N2[C@H](C(O)=O)CCC2 |
Biological Activity
| Description | PAR3 (1-6) is a synthetic peptide that functions as an agonist for the protease-activated receptor (PAR1). This peptide corresponds to the first six residues of the amino-terminal tethered ligand sequence from human PAR3 and residues 39-44 from the full-length human sequence. PAR3 (1-6) effectively activates p42/44 MAPK signaling pathways in fibroblasts that express PAR1, an activation that can be inhibited by the PAR1 antagonist RWJ 56110. This reagent is valuable for research involving receptor signaling mechanisms and cellular responses to proteolytic activation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
