Product Data Sheet
Q94 hydrochloride
Catalog No. A63492
Q94 hydrochloride is a selective antagonist of the protease-activated receptor 1 (PAR1), with an IC50 value of 916 nM. It inhibits PAR1/Gαq interaction and signaling, effectively preventing PAR1-mediated increases in CCL2 mRNA and protein levels in a dose-dependent manner. Additionally, Q94 hydrochloride completely blocks thrombin-induced phosphorylation of ERK1/2 and MLC, making it a valuable tool for investigating PAR1-related pathways in various biological research applications.
Chemical Information
| Catalog Num | A63492 |
|---|---|
| M. Wt | 369.29 |
| Formula | C21H18Cl2N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1052076-77-3 |
| Synonyms | |
| SMILES | ClC1=CC=C(CN2C3=CC=CC=C3N=C2CC4=CC=CC=C4)C=C1.Cl |
Biological Activity
| Description | Q94 hydrochloride is a selective antagonist of the protease-activated receptor 1 (PAR1), with an IC50 value of 916 nM. It inhibits PAR1/Gαq interaction and signaling, effectively preventing PAR1-mediated increases in CCL2 mRNA and protein levels in a dose-dependent manner. Additionally, Q94 hydrochloride completely blocks thrombin-induced phosphorylation of ERK1/2 and MLC, making it a valuable tool for investigating PAR1-related pathways in various biological research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
