Product Data Sheet
RP03707
Catalog No. A63530
RP03707 is a potent PROTAC degrader targeting KRASG12D. By forming a ternary complex with KRASG12D and the CRBN E3 ligase, RP03707 facilitates the ubiquitination and subsequent proteasomal degradation of KRASG12D. This compound demonstrates significant inhibitory effects on the growth of KRASG12D-positive tumor cells, making it an essential tool for research in cancer biology and targeted therapy development.
Chemical Information
| Catalog Num | A63530 |
|---|---|
| M. Wt | 994.12 |
| Formula | C55H58F3N11O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3030493-05-8 |
| Synonyms | |
| SMILES | O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(C4CCN(C5CC6(CCN(CC7(COC8=NC9=C(C=NC(C%10=C%11C(C#C)=C(F)C=CC%11=CC(O)=C%10)=C9F)C(N%12C[C@H]%13N[C@H](CC%13)C%12)=N8)CC7)CC6)C5)CC4)=C3)=O |
Biological Activity
| Description | RP03707 is a potent PROTAC degrader targeting KRASG12D. By forming a ternary complex with KRASG12D and the CRBN E3 ligase, RP03707 facilitates the ubiquitination and subsequent proteasomal degradation of KRASG12D. This compound demonstrates significant inhibitory effects on the growth of KRASG12D-positive tumor cells, making it an essential tool for research in cancer biology and targeted therapy development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
