Product Data Sheet
PROTAC K-Ras Degrader-3
Catalog No. A63536
PROTAC K-Ras Degrader-3 is a powerful PROTAC compound designed to target and degrade K-Ras, demonstrating a DC50 of ≤ 1 nM in SW620 KRAS G12D cells and a GI50 of ≤ 10 nM for inhibiting SW620 3D cell growth. This compound is particularly valuable in cancer research, especially for studying non-small-cell lung cancer (NSCLC). Its unique design incorporates a K-RAS ligand, a Cereblon ligand, and a linker, facilitating targeted degradation and offering insights into K-Ras-related pathways.
Chemical Information
| Catalog Num | A63536 |
|---|---|
| M. Wt | 1012.20 |
| Formula | C57H67F2N9O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3043670-68-1 |
| Synonyms | |
| SMILES | FC1=C(CC)C2=C(C3=C(F)C4=NC(OCC5(CC5)CN6CCC(CN7CC8(CCN(C9=CC=C(C(N([C@@H]%10C(NC(CC%10)=O)=O)C%11)=O)C%11=C9)CC8)C7)(C)CC6)=NC(N%12C[C@@](O)(C)CCC%12)=C4C=N3)C=C(O)C=C2C=C1 |
Biological Activity
| Description | PROTAC K-Ras Degrader-3 is a powerful PROTAC compound designed to target and degrade K-Ras, demonstrating a DC50 of ≤ 1 nM in SW620 KRAS G12D cells and a GI50 of ≤ 10 nM for inhibiting SW620 3D cell growth. This compound is particularly valuable in cancer research, especially for studying non-small-cell lung cancer (NSCLC). Its unique design incorporates a K-RAS ligand, a Cereblon ligand, and a linker, facilitating targeted degradation and offering insights into K-Ras-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
