Product Data Sheet
ADT-1004
Catalog No. A63556
ADT-1004 is an orally active prodrug of the pan-RAS inhibitor ADT-007, which is characterized by its reversible, high potency and selectivity. By binding to the nucleotide-free conformation of RAS proteins, ADT-007 effectively inhibits GTP activation, subsequently blocking downstream MAPK and AKT signaling pathways. ADT-1004 is primarily utilized in research focused on pancreatic ductal adenocarcinoma, providing a valuable tool for the investigation of RAS-mediated oncogenic processes.
Chemical Information
| Catalog Num | A63556 |
|---|---|
| M. Wt | 589.65 |
| Formula | C33H36FN3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1945941-72-9 |
| Synonyms | |
| SMILES | O=C(NCC1=CC=CO1)CC2=C(C)/C(C3=CC=C(F)C=C32)=C/C4=CC(OC)=C(C(OC)=C4)OC(NC5CCN(CC5)C)=O |
Biological Activity
| Description | ADT-1004 is an orally active prodrug of the pan-RAS inhibitor ADT-007, which is characterized by its reversible, high potency and selectivity. By binding to the nucleotide-free conformation of RAS proteins, ADT-007 effectively inhibits GTP activation, subsequently blocking downstream MAPK and AKT signaling pathways. ADT-1004 is primarily utilized in research focused on pancreatic ductal adenocarcinoma, providing a valuable tool for the investigation of RAS-mediated oncogenic processes. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
