Product Data Sheet
GGTI-286
Catalog No. A63564
GGTI-286 is a selective inhibitor of geranylgeranyl transferase I (GGTase I) with an IC50 of 2 μM, demonstrating 25-fold increased potency compared to its methyl ester derivative. It effectively inhibits the geranylgeranylation of Rap1A while displaying a lower impact on the farnesylation of H-Ras, with IC50 values of 2 μM and >30 μM, respectively. Additionally, GGTI-286 shows strong inhibition of oncogenic K-Ras4B stimulation, with an IC50 of 1 μM, making it a valuable tool for research in cancer biology and signaling pathways.
Chemical Information
| Catalog Num | A63564 |
|---|---|
| M. Wt | 429.58 |
| Formula | C23H31N3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 171744-11-9 |
| Synonyms | |
| SMILES | CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O |
Biological Activity
| Description | GGTI-286 is a selective inhibitor of geranylgeranyl transferase I (GGTase I) with an IC50 of 2 μM, demonstrating 25-fold increased potency compared to its methyl ester derivative. It effectively inhibits the geranylgeranylation of Rap1A while displaying a lower impact on the farnesylation of H-Ras, with IC50 values of 2 μM and >30 μM, respectively. Additionally, GGTI-286 shows strong inhibition of oncogenic K-Ras4B stimulation, with an IC50 of 1 μM, making it a valuable tool for research in cancer biology and signaling pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
