Product Data Sheet
PROTAC pan-KRAS degrader-1
Catalog No. A63583
PROTAC pan-KRAS degrader-1 targets pan-KRAS mutations, facilitating the degradation of various KRAS variants, including G12D, G12C, G12V, and G13D. This compound exhibits potent activity against the G12D mutation in AGS cells, achieving a DC50 of 1.1 nM and a maximum degradation efficacy (Dmax) of 95%. PROTAC pan-KRAS degrader-1 is a valuable tool for investigating diseases associated with KRAS mutations and amplifications, particularly in cancer types such as breast, bladder, and gastric cancer.
Chemical Information
| Catalog Num | A63583 |
|---|---|
| M. Wt | 1192.38 |
| Formula | C63H71F2N13O7S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3043908-63-7 |
| Synonyms | |
| SMILES | FC(C=C1)=C(CC)C(C1=CC(O)=C2)=C2C3=NC=C4C(N=C(OCC5(CC5)CN6CCC(OC7=NC=C(C8=CN([C@@H](C(C)C)C(N9C[C@H](O)C[C@H]9C(N[C@@H](C)C%10=CC=C(C%11=C(C)N=CS%11)C=C%10)=O)=O)N=N8)N=C7)CC6)N=C4N%12CCC[C@@](C)(O)C%12)=C3F |
Biological Activity
| Description | PROTAC pan-KRAS degrader-1 targets pan-KRAS mutations, facilitating the degradation of various KRAS variants, including G12D, G12C, G12V, and G13D. This compound exhibits potent activity against the G12D mutation in AGS cells, achieving a DC50 of 1.1 nM and a maximum degradation efficacy (Dmax) of 95%. PROTAC pan-KRAS degrader-1 is a valuable tool for investigating diseases associated with KRAS mutations and amplifications, particularly in cancer types such as breast, bladder, and gastric cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
