Product Data Sheet
MRTX849 acid
Catalog No. A63584
MRTX849 acid serves as a ligand for KRAS G12C, facilitating the synthesis of the PROTAC LC-2. This first-in-class PROTAC effectively induces degradation of endogenous KRAS G12C, demonstrating potent biological activity with DC50 values ranging from 0.25 to 0.76 μM. It is applicable in research settings focused on targeted protein degradation and cancer therapeutics.
| Catalog Num | A63584 |
|---|---|
| M. Wt | 662.15 |
| Formula | C34H37ClFN7O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2561529-96-0 |
| Synonyms | |
| SMILES | OC(CCN(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C(F)=C)=O)CC#N)=C4C(CN(C5=CC=CC6=C5C(Cl)=CC=C6)CC4)=N2)=O |
| Description | MRTX849 acid serves as a ligand for KRAS G12C, facilitating the synthesis of the PROTAC LC-2. This first-in-class PROTAC effectively induces degradation of endogenous KRAS G12C, demonstrating potent biological activity with DC50 values ranging from 0.25 to 0.76 μM. It is applicable in research settings focused on targeted protein degradation and cancer therapeutics. |
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