Product Data Sheet
IACS-56676
Catalog No. A63585
IACS-56676 is a selective inhibitor of the NRAS G12D mutation, with a binding affinity (Kd) of 0.031 μM. It stabilizes the p-loop and preserves critical interactions with key residues, including Asp12, Gly60, and Asp69, allowing for its specificity toward NRAS G12D while sparing wild-type KRAS through targeting Leu95. This compound is applicable in research focusing on melanoma, hematologic malignancies, and thyroid cancer, providing a valuable tool for investigating targeted therapies in these contexts.
Chemical Information
| Catalog Num | A63585 |
|---|---|
| M. Wt | 562.00 |
| Formula | C28H28ClF4N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3105153-34-9 |
| Synonyms | |
| SMILES | NC1=CC(C2=C(F)C(N(C3CC3)C(CNC(C)=O)=C4[C@@]5([H])[C@@]6([H])[C@]5([H])CNC6)=C4C(C7CC7)=N2)=C(C(F)(F)F)C(Cl)=C1 |
Biological Activity
| Description | IACS-56676 is a selective inhibitor of the NRAS G12D mutation, with a binding affinity (Kd) of 0.031 μM. It stabilizes the p-loop and preserves critical interactions with key residues, including Asp12, Gly60, and Asp69, allowing for its specificity toward NRAS G12D while sparing wild-type KRAS through targeting Leu95. This compound is applicable in research focusing on melanoma, hematologic malignancies, and thyroid cancer, providing a valuable tool for investigating targeted therapies in these contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
