Product Data Sheet
Spiclomazine
Catalog No. A63588
Spiclomazine is a selective inhibitor of mutant KRAS(G12C), targeting KRAS-driven pancreatic cancer. This compound effectively reduces KRas-GTP levels and inhibits downstream RAS-mediated signaling pathways. In preclinical studies, Spiclomazine demonstrates significant tumor progression inhibition in mouse renal capsule xenotransplantation models, making it a valuable tool for researching therapeutic strategies against KRAS-driven malignancies.
Chemical Information
| Catalog Num | A63588 |
|---|---|
| M. Wt | 446.03 |
| Formula | C22H24ClN3OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 24527-27-3 |
| Synonyms | Clospirazine |
| SMILES | O=C1CSC2(CCN(CCCN3C4=C(C=CC=C4)SC5=CC=C(Cl)C=C35)CC2)N1 |
Biological Activity
| Description | Spiclomazine is a selective inhibitor of mutant KRAS(G12C), targeting KRAS-driven pancreatic cancer. This compound effectively reduces KRas-GTP levels and inhibits downstream RAS-mediated signaling pathways. In preclinical studies, Spiclomazine demonstrates significant tumor progression inhibition in mouse renal capsule xenotransplantation models, making it a valuable tool for researching therapeutic strategies against KRAS-driven malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
