Product Data Sheet
Neogrifolin
Catalog No. A63614
Neogrifolin is a selective inhibitor of KRAS, which plays a critical role in the signaling pathways associated with cancer cell proliferation and survival. This compound has demonstrated significant anti-cell viability activity against human cancer cell lines, including HeLa (IC50: 24.3 μM), SW480 (IC50: 34.6 μM), and HT29 (IC50: 30.1 μM). Neogrifolin is primarily utilized in research applications aimed at elucidating the role of KRAS in tumorigenesis and investigating potential therapeutic strategies for KRAS-driven malignancies.
Chemical Information
| Catalog Num | A63614 |
|---|---|
| M. Wt | 328.49 |
| Formula | C22H32O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 23665-96-5 |
| Synonyms | |
| SMILES | OC1=CC(C)=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)C(O)=C1 |
Biological Activity
| Description | Neogrifolin is a selective inhibitor of KRAS, which plays a critical role in the signaling pathways associated with cancer cell proliferation and survival. This compound has demonstrated significant anti-cell viability activity against human cancer cell lines, including HeLa (IC50: 24.3 μM), SW480 (IC50: 34.6 μM), and HT29 (IC50: 30.1 μM). Neogrifolin is primarily utilized in research applications aimed at elucidating the role of KRAS in tumorigenesis and investigating potential therapeutic strategies for KRAS-driven malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
