Product Data Sheet
PROTAC K-Ras Degrader-2
Catalog No. A63618
PROTAC K-Ras Degrader-2 is a selective PROTAC degrader designed to target pan-KRAS mutants, exhibiting an IC50 of ≤200 nM against KRAS G12V and RAF1. This compound effectively degrades KRAS G12D in SW620 cells with a DC50 of ≤200 nM and inhibits cell growth in 3D cultures at an IC50 of ≤20 nM. PROTAC K-Ras Degrader-2 is a valuable tool for investigating therapeutic strategies in colorectal cancer research.
Chemical Information
| Catalog Num | A63618 |
|---|---|
| M. Wt | 953.08 |
| Formula | C52H60F4N8O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3043670-74-9 |
| Synonyms | |
| SMILES | FC1=C(C2=CC(O)=CC3=C2C(CC)=C(F)C=C3)N=CC4=C1N=C(N=C4N5C[C@](O)(CCC5)C)OCC6(CC6)CN7CCC(C)(CC7)CN8CCN(C9=CC(F)=C(C%10C(NC(CC%10)=O)=O)C(F)=C9)CC8 |
Biological Activity
| Description | PROTAC K-Ras Degrader-2 is a selective PROTAC degrader designed to target pan-KRAS mutants, exhibiting an IC50 of ≤200 nM against KRAS G12V and RAF1. This compound effectively degrades KRAS G12D in SW620 cells with a DC50 of ≤200 nM and inhibits cell growth in 3D cultures at an IC50 of ≤20 nM. PROTAC K-Ras Degrader-2 is a valuable tool for investigating therapeutic strategies in colorectal cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
