Product Data Sheet
pan-KRAS-IN-6
Catalog No. A63620
pan-KRAS-IN-6 is a highly potent pan-KRAS inhibitor, exhibiting IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V. This compound effectively targets KRAS mutant forms associated with various cancers, making it a valuable tool for studying KRAS signaling pathways and evaluating therapeutic strategies in KRAS-driven tumors. Its specificity and efficacy position it as a key reagent in cancer research and drug discovery efforts targeting KRAS-related malignancies.
Chemical Information
| Catalog Num | A63620 |
|---|---|
| M. Wt | 635.10 |
| Formula | C29H30ClF3N6O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3033565-36-2 |
| Synonyms | |
| SMILES | FC1=C(C2=C(N=C(N)S3)C3=C(F)C=C2)C(Cl)=CC4=C(N5CC(C)(O)COCC5)N=C(OC[C@@]6(CCC7)N7C[C@H](F)C6)N=C14 |
Biological Activity
| Description | pan-KRAS-IN-6 is a highly potent pan-KRAS inhibitor, exhibiting IC50 values of 9.79 nM for Kras G12D and 6.03 nM for Kras G12V. This compound effectively targets KRAS mutant forms associated with various cancers, making it a valuable tool for studying KRAS signaling pathways and evaluating therapeutic strategies in KRAS-driven tumors. Its specificity and efficacy position it as a key reagent in cancer research and drug discovery efforts targeting KRAS-related malignancies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
