Product Data Sheet
SOS1-IN-25
Catalog No. A63635
SOS1-IN-25 is a selective inhibitor of the SOS1 protein, effectively disrupting the formation of the KRASG12C/SOS1 complex with an IC50 of 11.11 nM. This compound demonstrates a dose-dependent reduction in phosphorylated ERK levels, indicating its potential to modulate downstream signaling pathways. SOS1-IN-25 is suitable for research focused on leukemia and other cancers associated with aberrant KRAS signaling.
Chemical Information
| Catalog Num | A63635 |
|---|---|
| M. Wt | 519.70 |
| Formula | C29H37N5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3092446-09-5 |
| Synonyms | |
| SMILES | CC1=NC(N[C@@H](C2=CC(C3=CC=CC=C3CNC)=CS2)C)=C4C(C(C)(C)C(N(C5CCOCC5)C4)=O)=N1 |
Biological Activity
| Description | SOS1-IN-25 is a selective inhibitor of the SOS1 protein, effectively disrupting the formation of the KRASG12C/SOS1 complex with an IC50 of 11.11 nM. This compound demonstrates a dose-dependent reduction in phosphorylated ERK levels, indicating its potential to modulate downstream signaling pathways. SOS1-IN-25 is suitable for research focused on leukemia and other cancers associated with aberrant KRAS signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
