Product Data Sheet
pan-KRAS-IN-13
Catalog No. A63642
pan-KRAS-IN-13 is a potent KRAS inhibitor that targets mutant forms of the KRAS protein, demonstrating IC50 values of 2.75 nM and 2.89 nM for G12D and G12V mutations, respectively. This compound is valuable for research applications aimed at understanding KRAS-driven cancers and evaluating therapeutic strategies to inhibit KRAS signaling pathways. Its high specificity and efficacy make it a critical tool for the study of oncogenic mutations associated with various malignancies.
Chemical Information
| Catalog Num | A63642 |
|---|---|
| M. Wt | 616.63 |
| Formula | C33H31F3N6O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3033637-76-9 |
| Synonyms | |
| SMILES | FC1=C(C#C)C2=C(C3=NC(OCC4)=C(C(N5[C@@H]4CNCC5)=NC(OC[C@]6(C[C@@H](F)C7)N7CCC6)=N8)C8=C3F)C=C(O)C=C2C=C1 |
Biological Activity
| Description | pan-KRAS-IN-13 is a potent KRAS inhibitor that targets mutant forms of the KRAS protein, demonstrating IC50 values of 2.75 nM and 2.89 nM for G12D and G12V mutations, respectively. This compound is valuable for research applications aimed at understanding KRAS-driven cancers and evaluating therapeutic strategies to inhibit KRAS signaling pathways. Its high specificity and efficacy make it a critical tool for the study of oncogenic mutations associated with various malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
