Product Data Sheet
MRTX849 ethoxypropanoic acid
Catalog No. A63717
MRTX849 ethoxypropanoic acid is a targeted protein ligand-linker conjugate designed for the selective degradation of KRAS G12C. This compound incorporates a specific ligand that binds to KRAS G12C and a PROTAC linker, facilitating the synthesis of PROTAC LC-2, an innovative compound known for its ability to degrade endogenous KRAS G12C with IC50 values ranging from 0.25 to 0.76 µM. MRTX849 ethoxypropanoic acid is essential for research applications focused on targeted protein degradation and cancer therapeutics involving KRAS mutations.
Chemical Information
| Catalog Num | A63717 |
|---|---|
| M. Wt | 720.23 |
| Formula | C37H43ClFN7O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2561529-98-2 |
| Synonyms | |
| SMILES | O=C(N1CCN(C2=C3CCN(CC3=NC(OC[C@@H]4CCCN4CCCOCCC(O)=O)=N2)C5=CC=CC6=C5C(Cl)=CC=C6)C[C@@H]1CC#N)C(F)=C |
Biological Activity
| Description | MRTX849 ethoxypropanoic acid is a targeted protein ligand-linker conjugate designed for the selective degradation of KRAS G12C. This compound incorporates a specific ligand that binds to KRAS G12C and a PROTAC linker, facilitating the synthesis of PROTAC LC-2, an innovative compound known for its ability to degrade endogenous KRAS G12C with IC50 values ranging from 0.25 to 0.76 µM. MRTX849 ethoxypropanoic acid is essential for research applications focused on targeted protein degradation and cancer therapeutics involving KRAS mutations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
