Product Data Sheet
pan-KRAS-IN-16
Catalog No. A63741
pan-KRAS-IN-16 is a potent RAS inhibitor that disrupts protein-protein interactions involving RAS effector proteins. This small molecule, derived from an intracellular antibody fragment, binds to a hydrophobic pocket adjacent to the effector-binding switch regions of RAS. By inhibiting these interactions, pan-KRAS-IN-16 effectively blocks endogenous RAS-dependent signaling in tumor cell lines, making it a valuable tool for research in cancer biology and therapeutic development targeting RAS mutation-driven malignancies.
Chemical Information
| Catalog Num | A63741 |
|---|---|
| M. Wt | 390.47 |
| Formula | C24H26N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2368246-78-8 |
| Synonyms | |
| SMILES | CN(C)CC1=CC(NC2=CC=C(C3=C4OCCOC4=CC=C3)C=C2OC)=CC=C1 |
Biological Activity
| Description | pan-KRAS-IN-16 is a potent RAS inhibitor that disrupts protein-protein interactions involving RAS effector proteins. This small molecule, derived from an intracellular antibody fragment, binds to a hydrophobic pocket adjacent to the effector-binding switch regions of RAS. By inhibiting these interactions, pan-KRAS-IN-16 effectively blocks endogenous RAS-dependent signaling in tumor cell lines, making it a valuable tool for research in cancer biology and therapeutic development targeting RAS mutation-driven malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
