Product Data Sheet
SAH-SOS1A
Catalog No. A63768
SAH-SOS1A is a peptide-based inhibitor targeting the SOS1/KRAS protein interaction. It binds with nanomolar affinity (EC50 = 106-175 nM) to both wild-type and various mutant forms of KRAS, including G12D, G12V, G12C, G12S, and Q61H. By directly obstructing nucleotide association, SAH-SOS1A interferes with KRAS-driven cancer cell viability and inhibits the ERK-MAPK phosphosignaling cascade downstream of KRAS, making it a valuable tool for cancer research and therapeutic exploration.
Chemical Information
| Catalog Num | A63768 |
|---|---|
| M. Wt | 2187.50 |
| Formula | C100H159N27O28 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1652561-87-9 |
| Synonyms | |
| SMILES | [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@H](C(N[C@]3(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(N)=O)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CC(C)C)=O)(C)CCCC=CCCC3)[H])=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O |
Biological Activity
| Description | SAH-SOS1A is a peptide-based inhibitor targeting the SOS1/KRAS protein interaction. It binds with nanomolar affinity (EC50 = 106-175 nM) to both wild-type and various mutant forms of KRAS, including G12D, G12V, G12C, G12S, and Q61H. By directly obstructing nucleotide association, SAH-SOS1A interferes with KRAS-driven cancer cell viability and inhibits the ERK-MAPK phosphosignaling cascade downstream of KRAS, making it a valuable tool for cancer research and therapeutic exploration. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
