Product Data Sheet
Advantame
Catalog No. A63938
Advantame is an N-substituted derivative of aspartame that primarily functions as a high-intensity, low-calorie sweetener. This compound interacts with plasma proteins and has been shown to potentially induce hypotension and inhibit the hERG K+ channel, raising concerns for cardiotoxicity. Advantame activates the T1R2/T1R3 taste G protein-coupled receptor (GPCR), promoting oligomeric functional selectivity and enhancing sialidase activity in vitro. Additionally, in prenatal developmental toxicity studies on rabbits, Advantame has displayed maternal toxicity characterized by gastrointestinal disturbances.
Chemical Information
| Catalog Num | A63938 |
|---|---|
| M. Wt | 476.52 |
| Formula | C24H32N2O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 714229-20-6 |
| Synonyms | |
| SMILES | OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1.O |
Biological Activity
| Description | Advantame is an N-substituted derivative of aspartame that primarily functions as a high-intensity, low-calorie sweetener. This compound interacts with plasma proteins and has been shown to potentially induce hypotension and inhibit the hERG K+ channel, raising concerns for cardiotoxicity. Advantame activates the T1R2/T1R3 taste G protein-coupled receptor (GPCR), promoting oligomeric functional selectivity and enhancing sialidase activity in vitro. Additionally, in prenatal developmental toxicity studies on rabbits, Advantame has displayed maternal toxicity characterized by gastrointestinal disturbances. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
