Product Data Sheet
20-Hydroxyvitamin D3
Catalog No. A64098
20-Hydroxyvitamin D3 serves as a VDR agonist, modulating immune responses without inducing calcemia. By binding to the vitamin D receptor (VDR), it activates VDR and aryl hydrocarbon receptor (AhR) signaling pathways, enhances CYP24A1 expression, and promotes VDR nuclear translocation. This compound inhibits NF-κB activity through IκBα upregulation, demonstrating anti-proliferative effects in cancer cells by reducing cell proliferation, colony formation, migration, and tumor growth while inducing differentiation. 20-Hydroxyvitamin D3 is a valuable tool for investigating inflammatory and autoimmune diseases, as well as various cancers, including melanoma and hepatocarcinoma.
Chemical Information
| Catalog Num | A64098 |
|---|---|
| M. Wt | 400.64 |
| Formula | C27H44O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 651734-12-2 |
| Synonyms | 20(OH)D3; 20S-Hydroxyvitamin D3 |
| SMILES | C=C1CC[C@H](O)C/C1=C/C=C2[C@@](CC[C@]3([H])[C@@](C)(O)CCCC(C)C)([H])[C@]3(C)CCC/2 |
Biological Activity
| Description | 20-Hydroxyvitamin D3 serves as a VDR agonist, modulating immune responses without inducing calcemia. By binding to the vitamin D receptor (VDR), it activates VDR and aryl hydrocarbon receptor (AhR) signaling pathways, enhances CYP24A1 expression, and promotes VDR nuclear translocation. This compound inhibits NF-κB activity through IκBα upregulation, demonstrating anti-proliferative effects in cancer cells by reducing cell proliferation, colony formation, migration, and tumor growth while inducing differentiation. 20-Hydroxyvitamin D3 is a valuable tool for investigating inflammatory and autoimmune diseases, as well as various cancers, including melanoma and hepatocarcinoma. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
