Product Data Sheet
Modakafusp alfa
Catalog No. A64186
Modakafusp alfa is a humanized anti-CD38 IgG4 monoclonal antibody fused with two attenuated interferon-alpha 2b molecules, targeting CD38-expressing cells. It exhibits direct anti-proliferative activity against multiple myeloma cells in vitro and elicits significant and sustained antitumor responses in xenograft tumor models. Additionally, the combination of Modakafusp alfa with anti-PD-1 antibodies promotes immunomodulation and enhances antitumor efficacy, demonstrating a favorable tolerance profile in murine models. This reagent is valuable for research in multiple myeloma therapy and immune checkpoint modulation.
Chemical Information
| Catalog Num | A64186 |
|---|---|
| M. Wt | 183.48 kDa |
| Formula | |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2254522-19-3 |
| Synonyms | TAK-573 |
| SMILES | [Modakafusp alfa] |
Biological Activity
| Description | Modakafusp alfa is a humanized anti-CD38 IgG4 monoclonal antibody fused with two attenuated interferon-alpha 2b molecules, targeting CD38-expressing cells. It exhibits direct anti-proliferative activity against multiple myeloma cells in vitro and elicits significant and sustained antitumor responses in xenograft tumor models. Additionally, the combination of Modakafusp alfa with anti-PD-1 antibodies promotes immunomodulation and enhances antitumor efficacy, demonstrating a favorable tolerance profile in murine models. This reagent is valuable for research in multiple myeloma therapy and immune checkpoint modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
