Product Data Sheet
Ampyrone-d3
Catalog No. A64332
Ampyrone-d3 is a deuterium-labeled derivative of Ampyrone, a reversible and low-damage optical clearing agent that acts as a non-selective inhibitor of cyclooxygenase (COX). It enhances optical transmittance in mouse skin and other tissues by inducing tissue refractive index matching through improved UV absorption, thereby facilitating tissue transparency in vivo. Additionally, Ampyrone-d3 exhibits anti-inflammatory, analgesic, and antipyretic activities by inhibiting the synthesis of prostaglandin PGE2 and is involved in mitigating DNA damage, apoptosis, and immune cell phagocytosis during chemotherapy with agents such as Doxorubicin and Cisplatin. This compound is valuable for research in optical imaging and cancer therapeutics.
Chemical Information
| Catalog Num | A64332 |
|---|---|
| M. Wt | 206.26 |
| Formula | C11H10D3N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1329792-51-9 |
| Synonyms | 4-Aminoantipyrine-d3 |
| SMILES | O=C1N(C2=CC=CC=C2)N(C(C)=C1N)C([2H])([2H])[2H] |
Biological Activity
| Description | Ampyrone-d3 is a deuterium-labeled derivative of Ampyrone, a reversible and low-damage optical clearing agent that acts as a non-selective inhibitor of cyclooxygenase (COX). It enhances optical transmittance in mouse skin and other tissues by inducing tissue refractive index matching through improved UV absorption, thereby facilitating tissue transparency in vivo. Additionally, Ampyrone-d3 exhibits anti-inflammatory, analgesic, and antipyretic activities by inhibiting the synthesis of prostaglandin PGE2 and is involved in mitigating DNA damage, apoptosis, and immune cell phagocytosis during chemotherapy with agents such as Doxorubicin and Cisplatin. This compound is valuable for research in optical imaging and cancer therapeutics. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
