Product Data Sheet
8,11,14-Eicosatriynoic acid
Catalog No. A64345
8,11,14-Eicosatriynoic Acid functions as a biochemical assay reagent primarily targeting the inhibition of prostaglandin and leukotriene biosynthesis. It effectively inhibits human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. This compound also demonstrates inhibition of slow-reacting substances involved in allergic reactions, with an IC50 of 10 μM. Beyond its role in modulating inflammatory pathways, 8,11,14-Eicosatriynoic Acid serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition. Its multifaceted applications are valuable in exploring disease mechanisms, particularly in cancer and oxidative stress conditions.
Chemical Information
| Catalog Num | A64345 |
|---|---|
| M. Wt | 300.44 |
| Formula | C20H28O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 34262-64-1 |
| Synonyms | 8,11,14-Icosatriynoic acid |
| SMILES | CCCCCC#CCC#CCC#CCCCCCCC(O)=O |
Biological Activity
| Description | 8,11,14-Eicosatriynoic Acid functions as a biochemical assay reagent primarily targeting the inhibition of prostaglandin and leukotriene biosynthesis. It effectively inhibits human 12-lipoxygenase (12-LO), cyclooxygenase (COX), and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μM, and 25 μM, respectively. This compound also demonstrates inhibition of slow-reacting substances involved in allergic reactions, with an IC50 of 10 μM. Beyond its role in modulating inflammatory pathways, 8,11,14-Eicosatriynoic Acid serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition. Its multifaceted applications are valuable in exploring disease mechanisms, particularly in cancer and oxidative stress conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
