Product Data Sheet
Tolfenamic acid-d4
Catalog No. A64366
Tolfenamic acid-d4 is a deuterated form of Tolfenamic Acid, a selective non-steroidal anti-inflammatory drug that primarily targets cyclooxygenase-2 (COX-2). It exhibits significant anti-inflammatory and potential anti-cancer properties, with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while having no impact on COX-1 activity. Tolfenamic acid-d4 can be utilized in various research applications, including studies focused on inflammation and cancer biology, as well as in pharmacokinetic and metabolic profiling.
Chemical Information
| Catalog Num | A64366 |
|---|---|
| M. Wt | 265.73 |
| Formula | C14H8D4ClNO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1246820-82-5 |
| Synonyms | |
| SMILES | OC(C(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C(Cl)=CC=C2)C)=O |
Biological Activity
| Description | Tolfenamic acid-d4 is a deuterated form of Tolfenamic Acid, a selective non-steroidal anti-inflammatory drug that primarily targets cyclooxygenase-2 (COX-2). It exhibits significant anti-inflammatory and potential anti-cancer properties, with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while having no impact on COX-1 activity. Tolfenamic acid-d4 can be utilized in various research applications, including studies focused on inflammation and cancer biology, as well as in pharmacokinetic and metabolic profiling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
