Product Data Sheet
Tolfenamic acid-13C6
Catalog No. A64441
Tolfenamic acid-13C6 is a stable isotope-labeled derivative of Tolfenamic acid, a non-steroidal anti-inflammatory and anti-cancer agent. It selectively inhibits COX-2 with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while exhibiting no inhibitory effect on COX-1. This reagent is valuable for studying COX-2-related pathways and assessing the pharmacokinetics and metabolism of Tolfenamic acid in various biological contexts.
Chemical Information
| Catalog Num | A64441 |
|---|---|
| M. Wt | 267.66 |
| Formula | C813C6H12ClNO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1420043-61-3 |
| Synonyms | GEA 6414-13C6 |
| SMILES | OC([13C]([13CH]=[13CH][13CH]=[13CH]1)=[13C]1NC2=C(C(Cl)=CC=C2)C)=O |
Biological Activity
| Description | Tolfenamic acid-13C6 is a stable isotope-labeled derivative of Tolfenamic acid, a non-steroidal anti-inflammatory and anti-cancer agent. It selectively inhibits COX-2 with an IC50 of 13.49 μM in LPS-treated canine DH82 monocyte/macrophage cells, while exhibiting no inhibitory effect on COX-1. This reagent is valuable for studying COX-2-related pathways and assessing the pharmacokinetics and metabolism of Tolfenamic acid in various biological contexts. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
