Product Data Sheet
CP-394531
Catalog No. A64699
CP-394531 is a highly selective non-steroidal antagonist of the glucocorticoid receptor (GR), exhibiting a Ki value of 0.1 nM. It demonstrates minimal binding to the androgen receptor (AR) (Ki = 130 nM) and negligible effects on the progesterone receptor and estrogen receptors (ERα, ERβ). CP-394531 effectively inhibits the agonistic effects of Dexamethasone with a Kif of 4.1 nM. This compound is valuable for researching a variety of conditions, including diabetes, obesity, depression, neurodegenerative disorders, glaucoma, and Cushing's disease.
Chemical Information
| Catalog Num | A64699 |
|---|---|
| M. Wt | 366.88 |
| Formula | C23H23ClO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 305822-63-3 |
| Synonyms | |
| SMILES | O[C@@]1(C#CCl)C[C@@]2([H])CCC3=C(C=CC(O)=C3)[C@]2(CC4=CC=CC=C4)CC1 |
Biological Activity
| Description | CP-394531 is a highly selective non-steroidal antagonist of the glucocorticoid receptor (GR), exhibiting a Ki value of 0.1 nM. It demonstrates minimal binding to the androgen receptor (AR) (Ki = 130 nM) and negligible effects on the progesterone receptor and estrogen receptors (ERα, ERβ). CP-394531 effectively inhibits the agonistic effects of Dexamethasone with a Kif of 4.1 nM. This compound is valuable for researching a variety of conditions, including diabetes, obesity, depression, neurodegenerative disorders, glaucoma, and Cushing's disease. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
