Product Data Sheet
ZK 216348
Catalog No. A64714
ZK 216348 is a selective nonsteroidal glucocorticoid receptor agonist, exhibiting an IC50 of 20.3 nM. This compound also interacts with progesterone and mineralocorticoid receptors, with IC50 values of 20.4 nM and 79.9 nM, respectively. ZK 216348 demonstrates significant anti-inflammatory properties comparable to those of Prednisolone while minimizing transactivation-related side effects, making it a valuable tool for research in inflammation and related conditions.
Chemical Information
| Catalog Num | A64714 |
|---|---|
| M. Wt | 476.45 |
| Formula | C24H23F3N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 669073-68-1 |
| Synonyms | (+)-ZK 216348 |
| SMILES | O=C1C2=CC=C(C=C2C(C)=NO1)NC(C(C(F)(F)F)(O)CC(C)(C3=C4C(CCO4)=CC=C3)C)=O |
Biological Activity
| Description | ZK 216348 is a selective nonsteroidal glucocorticoid receptor agonist, exhibiting an IC50 of 20.3 nM. This compound also interacts with progesterone and mineralocorticoid receptors, with IC50 values of 20.4 nM and 79.9 nM, respectively. ZK 216348 demonstrates significant anti-inflammatory properties comparable to those of Prednisolone while minimizing transactivation-related side effects, making it a valuable tool for research in inflammation and related conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
