Product Data Sheet
Dagrocorat hydrochloride
Catalog No. A64748
Dagrocorat hydrochloride is a selective partial agonist of the glucocorticoid receptor, exhibiting high affinity and oral bioavailability. This compound functions as a time-dependent reversible inhibitor of CYP3A and CYP2D6, demonstrating inhibitory activity with IC50 values of 1.3 μM and Ki of 0.57 μM, respectively, in human liver microsomes. Dagrocorat hydrochloride is primarily utilized in research related to rheumatoid arthritis, facilitating studies on glucocorticoid signaling pathways and related therapeutic applications.
Chemical Information
| Catalog Num | A64748 |
|---|---|
| M. Wt | 531.01 |
| Formula | C29H30ClF3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1044535-61-6 |
| Synonyms | PF-00251802 hydrochloride |
| SMILES | O[C@@]1(C(F)(F)F)C[C@]2([H])[C@](C3=CC=C(C(NC(C=CC=N4)=C4C)=O)C=C3CC2)(CC1)CC5=CC=CC=C5.[H]Cl |
Biological Activity
| Description | Dagrocorat hydrochloride is a selective partial agonist of the glucocorticoid receptor, exhibiting high affinity and oral bioavailability. This compound functions as a time-dependent reversible inhibitor of CYP3A and CYP2D6, demonstrating inhibitory activity with IC50 values of 1.3 μM and Ki of 0.57 μM, respectively, in human liver microsomes. Dagrocorat hydrochloride is primarily utilized in research related to rheumatoid arthritis, facilitating studies on glucocorticoid signaling pathways and related therapeutic applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
