Product Data Sheet
5α-Tetrahydrocorticosterone
Catalog No. A64749
5α-Tetrahydrocorticosterone is a potent glucocorticoid receptor agonist and a metabolite of corticosterone. It exhibits significant anti-inflammatory activity when applied topically, making it valuable for studying inflammatory skin conditions. In rat hepatocyte studies, it effectively reduces metabolites that bind to the glucocorticoid receptor, demonstrating a dissociation constant (Kd) of 268 nM. This compound is suitable for research focused on the mechanisms of glucocorticoid action and its therapeutic potential in skin inflammation.
Chemical Information
| Catalog Num | A64749 |
|---|---|
| M. Wt | 350.49 |
| Formula | C21H34O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 600-63-5 |
| Synonyms | 5α-THB |
| SMILES | C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C2 |
Biological Activity
| Description | 5α-Tetrahydrocorticosterone is a potent glucocorticoid receptor agonist and a metabolite of corticosterone. It exhibits significant anti-inflammatory activity when applied topically, making it valuable for studying inflammatory skin conditions. In rat hepatocyte studies, it effectively reduces metabolites that bind to the glucocorticoid receptor, demonstrating a dissociation constant (Kd) of 268 nM. This compound is suitable for research focused on the mechanisms of glucocorticoid action and its therapeutic potential in skin inflammation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
