Product Data Sheet
Glucocorticoid receptor-IN-2
Catalog No. A64794
Glucocorticoid receptor-IN-2 is a selective modulator of the glucocorticoid receptor (GR) that exhibits significant anti-inflammatory properties. This compound demonstrates notable transcriptional repressive activity with an IC50 of 0.171 nM against human matrix metalloproteinase 1 (hMMP1), while also showing comparable transcriptional activation activity with an EC50 of 0.94 nM against mouse mammary tumor virus (MMTV). It is a valuable reagent for research into GR-mediated pathways and the development of therapies targeting inflammation.
Chemical Information
| Catalog Num | A64794 |
|---|---|
| M. Wt | 512.46 |
| Formula | C25H20F4N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2664932-65-2 |
| Synonyms | |
| SMILES | CC(F)(F)C(N[C@@H](C)[C@@H](C1=CC(F)=CC(F)=C1)OC2=CC=C(N(C3=CN4C(C=C3)=NN=C4)N=C5)C5=C2)=O |
Biological Activity
| Description | Glucocorticoid receptor-IN-2 is a selective modulator of the glucocorticoid receptor (GR) that exhibits significant anti-inflammatory properties. This compound demonstrates notable transcriptional repressive activity with an IC50 of 0.171 nM against human matrix metalloproteinase 1 (hMMP1), while also showing comparable transcriptional activation activity with an EC50 of 0.94 nM against mouse mammary tumor virus (MMTV). It is a valuable reagent for research into GR-mediated pathways and the development of therapies targeting inflammation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
