Product Data Sheet
InsB (9-23)
Catalog No. A64847
InsB (9-23) is an MHC class II-restricted peptide derived from the insulin B-chain, encompassing amino acid residues 9-23. This peptide is a critical antigen for HLA-DQ8, facilitating T cell recognition and activation, leading to the release of IFN-γ and various cytokines. InsB (9-23) has been shown to activate CD4 T cells associated with the pathogenesis of type 1 diabetes and autoimmune diabetes. It serves as an essential tool for research investigating the immunological mechanisms underlying these diseases.
Chemical Information
| Catalog Num | A64847 |
|---|---|
| M. Wt | 1645.90 |
| Formula | C72H116N20O22S1 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 163364-16-7 |
| Synonyms | Insulin B chain (9-23) |
| SMILES | [C@H](CC1=CC=C(O)C=C1)(C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCNC(=N)N)C(NCC(O)=O)=O)=O)CCC(O)=O)=O)=O)CS)=O)[C@@H](C)C)=O)CC(C)C)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CO)N)=O)=O)CC(C)C)=O)[C@@H](C)C)=O)CCC(O)=O)=O)C)=O)CC(C)C)=O |
Biological Activity
| Description | InsB (9-23) is an MHC class II-restricted peptide derived from the insulin B-chain, encompassing amino acid residues 9-23. This peptide is a critical antigen for HLA-DQ8, facilitating T cell recognition and activation, leading to the release of IFN-γ and various cytokines. InsB (9-23) has been shown to activate CD4 T cells associated with the pathogenesis of type 1 diabetes and autoimmune diabetes. It serves as an essential tool for research investigating the immunological mechanisms underlying these diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
