Product Data Sheet
Feniralstat hydrochloride
Catalog No. A64980
Feniralstat hydrochloride is a potent inhibitor of kallikrein, with an IC50 value of 6.7 nM for human plasma kallikrein (pKal). This pyrazole derivative exhibits selectivity, showing no significant inhibition on human Kallikrein KLKl, FXIa, or Factor XIIa (IC50 values greater than 40 μM). Feniralstat is useful in research applications studying kallikrein's role in various biological processes and disease states, particularly in conditions associated with dysregulated kallikrein activity.
Chemical Information
| Catalog Num | A64980 |
|---|---|
| M. Wt | 545.97 |
| Formula | C26H26ClF2N5O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2340299-00-3 |
| Synonyms | |
| SMILES | O=C1C=CC(F)=CN1CC2=CC=C(CN3N=C(COC)C(C(NCC4=NC=CC(OC)=C4F)=O)=C3)C=C2.Cl |
Biological Activity
| Description | Feniralstat hydrochloride is a potent inhibitor of kallikrein, with an IC50 value of 6.7 nM for human plasma kallikrein (pKal). This pyrazole derivative exhibits selectivity, showing no significant inhibition on human Kallikrein KLKl, FXIa, or Factor XIIa (IC50 values greater than 40 μM). Feniralstat is useful in research applications studying kallikrein's role in various biological processes and disease states, particularly in conditions associated with dysregulated kallikrein activity. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
