Product Data Sheet
GW274150 phosphate
Catalog No. A65084
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways.
Chemical Information
| Catalog Num | A65084 |
|---|---|
| M. Wt | 317.30 |
| Formula | C8H20N3O6PS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 438542-15-5 |
| Synonyms | |
| SMILES | CC(NCCSCC[C@H](N)C(O)=O)=N.O=P(O)(O)O |
Biological Activity
| Description | GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
