Product Data Sheet
Banoxantrone
Catalog No. A65121
Banoxantrone, a hypoxia-selective cytotoxin, functions as a potent inhibitor of topoisomerase II after undergoing reduction to AQ4. It selectively targets and induces cell death in hypoxic environments through an iNOS-dependent mechanism. Additionally, Banoxantrone demonstrates significant cytotoxicity and synergizes with radiation to enhance its therapeutic effects, making it useful in cancer research focused on hypoxic tumors.
Chemical Information
| Catalog Num | A65121 |
|---|---|
| M. Wt | 444.48 |
| Formula | C22H28N4O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 136470-65-0 |
| Synonyms | AQ4N |
| SMILES | O=C1C2=C(C(O)=CC=C2O)C(C3=C(NCC[N+](C)(C)[O-])C=CC(NCC[N+](C)(C)[O-])=C13)=O |
Biological Activity
| Description | Banoxantrone, a hypoxia-selective cytotoxin, functions as a potent inhibitor of topoisomerase II after undergoing reduction to AQ4. It selectively targets and induces cell death in hypoxic environments through an iNOS-dependent mechanism. Additionally, Banoxantrone demonstrates significant cytotoxicity and synergizes with radiation to enhance its therapeutic effects, making it useful in cancer research focused on hypoxic tumors. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
