Product Data Sheet
SCR-4026
Catalog No. A65175
SCR-4026 is a neuroprotective agent that effectively penetrates the blood-brain barrier. It exerts its protective effects by disrupting the interaction between neuronal nitric oxide synthase (nNOS) and PSD9, with an IC50 of 6.3 μM. SCR-4026 has been shown to mitigate excitotoxic damage induced by N-methyl-D-aspartate (NMDA) in primary cortical neurons and offers protection in oxygen-glucose deprivation (OGD) models. Additionally, it reduces cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model, making it a valuable tool for stroke research.
Chemical Information
| Catalog Num | A65175 |
|---|---|
| M. Wt | 311.16 |
| Formula | C14H12Cl2N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2185855-51-8 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(COC2=C(N)C=C(Cl)C=C2Cl)C=C1)N |
Biological Activity
| Description | SCR-4026 is a neuroprotective agent that effectively penetrates the blood-brain barrier. It exerts its protective effects by disrupting the interaction between neuronal nitric oxide synthase (nNOS) and PSD9, with an IC50 of 6.3 μM. SCR-4026 has been shown to mitigate excitotoxic damage induced by N-methyl-D-aspartate (NMDA) in primary cortical neurons and offers protection in oxygen-glucose deprivation (OGD) models. Additionally, it reduces cerebral infarct volume in the rat middle cerebral artery occlusion (MCAO) reperfusion model, making it a valuable tool for stroke research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
